US findings suggesting ageing is not a slow and steady process could explain spikes in health issues at certain ages

cross-posted from: https://lemmy.world/post/18671978

If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

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  • graeghos_714@lemmy.worldEnglish
    0·
    3 months ago

    Getting T-Boned on my motorcycle when I was 62 made me real old, real fast because my mobility has been so reduced

    • cashmaggot@piefed.socialEnglish
      0·
      3 months ago

      Don’t give up, even if it absolutely fucking sucks. The people who give up never get it back. If you were wild enough to ride a motorcycle, you’re wild enough to invest into yourself. Because it takes guts to buy in to yourself. It’s a lot easier to just fade. I lost my mobility for a while and I fucking gave up. It made me feel like shit, and I literally spent weeks just laying in bed not really crying but feeling absolutely morose and like I had been cheated of the joy of the rest of my life. And it was fucking brutal. But I am so much more mobile and functional now than I was even a year ago and it takes so much time, effort, pain and realistic-hope (as in you can be optimistic, but also be kind to yourself and be a realist about where you are and where you’re trying to go and you’ll be a lot happier about all the small victories along the way). You might not even realize at some point how much your regained but I hope to god you find what you need and get back to some semblance of happiness.

      As for motorcycles, I am not sure I would ride them anymore nowadays because it seems like people are so brain-dead when they drive (Is it phones?) that they intentionally seem to go for folks. But safe healing, because you deserve it and even if you don’t get where you want to - don’t sell yourself short. Because that’s when stuff starts to fall apart bit by bit and I am sure you’ve still got more to live/give =)!

  • paddirn@lemmy.worldEnglish
    0·
    3 months ago

    Oh cool, on the cusp of some dramatic aging. Getting old sucks. We should go back to the time when we all died at an early age. Civilization was a mistake.

    • GoodEye8@lemm.eeEnglish
      0·
      3 months ago

      There was no time where we just died at an early age. The life span of humans has not changed, Cicero’s wife Terentia lived over 100 years . History has a low life expectancy because you were more likely to die from something else than old age.

      If by going back to the time where you died of plague you can just be anti modern medicine and get the same authentic experience.

      • Aggravationstation@feddit.ukEnglish
        0·
        3 months ago

        Also the infant mortality rate was very high for most of human history, reducing the average age of death considerably.

    • datelmd5sum@lemmy.worldEnglish
      0·
      3 months ago

      Have you tried 5000mg phentobarbital, 1000mg hydrocodone, 100mg alprazolam and 500ml of whiskey? I think this can cause almost immediate stop of the aging process.

  • int_not_found@feddit.orgEnglish
    0·
    3 months ago

    Well from personal experience I would argue that there are more than 2 points in life where you age dramatically, because never in my live I have been 44 or 60 years old, but still had at least one phase in live, where my body suddenly felt a lot older.

  • tiredofsametab@fedia.io
    0·
    3 months ago

    Actual study: https://www.nature.com/articles/s43587-024-00692-2

    We collected longitudinal biological samples from 108 participants over several years, with a median tracking period of 1.7 years and a maximum period of 6.8 years, and conducted multi-omics profiling on the samples.

    That’s not a lot of people studied for not a lot of time. It feels like the wording in the Guardian article is trying to misrepresent things.